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Related Experiment Video

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Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones

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Published on: February 5, 2018

[Why do good drugs disappear?].

Mayer Brezis¹, Ron Tomer, Samuel Klang

¹Center for Clinical Quality & Safety, Hadassah Hebrew University Medical Hospital, Jerusalem, Israel. brezis@vms.huji.ac.il

|May 17, 2011

Summary

Essential old medications are vanishing from the market, increasing healthcare costs and introducing safety uncertainties. Systemic revisions are crucial to ensure the continued availability of these safe and effective drugs.

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Area of Science:

Pharmacology
Health Economics
Regulatory Affairs

Context:

Established medications with proven safety and efficacy profiles are increasingly unavailable.
Examples include nitrofurantoin for urinary tract infections, alpha-methyldopa and hydralazine for pregnancy hypertension, and chlorthalidone for hypertension.
The withdrawal of these drugs necessitates transitions to newer agents, often at higher costs and with less established long-term safety data.

Purpose:

To highlight the issue of essential old drug unavailability.
To identify the contributing factors, including market failures and regulatory process deficiencies.
To advocate for systemic revisions to ensure the continued availability of safe and effective older medications.

Summary:

Old drugs with demonstrated efficacy and safety are disappearing from the market.
This trend impacts treatments for urinary tract infections, pregnancy hypertension, and general hypertension.
Reasons include market failures and production/regulatory issues, leading to increased costs and safety uncertainties with newer alternatives.

Impact:

Increased healthcare costs due to reliance on newer, more expensive medications.
Potential risks associated with the uncertainty of safety and efficacy of alternative drugs.
Urgent need for regulatory and market system reforms to preserve access to essential, cost-effective medicines.