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Updated: Jun 2, 2026

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
Direct aldol reactions catalyzed by a heterogeneous guanidinium salt/proline system under solvent-free conditions
Ángel Martínez-Castañeda1, Belén Poladura, Humberto Rodríguez-Solla
1Departamento de Química Orgánica e Inorgánica, Universidad de Oviedo, C/Julian Claveria 8, 33006, Oviedo, Spain.
Abstract:
The combined activity of (S)-proline and an achiral cocatalyst (a TBD-derived guanidinium salt) allow direct aldol reactions to be carried out with high diastereoselectivity and enantioselectivity under solvent-free conditions with a rather simple reaction setup where stirring is not required.
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