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An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

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Published on: December 3, 2020

Undulation instability of epithelial tissues.

Markus Basan¹, Jean-François Joanny, Jacques Prost

¹Institut Curie, Centre de Recherche, UMR 168, 26 rue d'Ulm, F-75005, Paris, France.

Physical Review Letters

|May 17, 2011

Summary

This summary is machine-generated.

A new hydrodynamic instability causes epithelial tissue to form finger-like protrusions into the underlying stroma. This finding offers insights into tissue growth and potential mechanisms of cancerous invasion.

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Area of Science:

Biophysics
Cell Biology
Tissue Engineering

Background:

Epithelial-stromal interactions are crucial in tissue development and disease.
Understanding tissue morphogenesis and invasion requires examining physical forces at the cellular level.

Purpose of the Study:

To investigate the physical mechanisms driving epithelial tissue deformation.
To identify potential causes of epithelial fingering observed in vivo.
To explore the link between tissue instability and cancerous invasion.

Main Methods:

Modeling the epithelium as an incompressible fluid and the stroma as viscoelastic.
Analyzing hydrodynamic instabilities at the epithelial-stromal interface.
Investigating the role of viscosity, cell division rate, and epithelial thickness.

Main Results:

A novel hydrodynamic instability was identified, causing epithelial protrusions into the stroma.
The instability is dependent on high viscosity, cell division rate, and epithelial thickness.
This phenomenon is a potential explanation for epithelial fingering observed in biological systems.

Conclusions:

The study reveals a physical mechanism for epithelial tissue undulation and protrusion.
This hydrodynamic instability may play a role in tissue dysplasia and cancerous invasion.
The findings provide a biophysical basis for understanding epithelial-stromal dynamics in health and disease.