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Updated: Jun 2, 2026
08:58
Murine Kidney Transplant Technique
Published on: October 20, 2015
Single-center experience with third and fourth kidney transplants.
Katrin Kienzl-Wagner1, Walter Mark, Manuel Maglione
1Center for Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria. katrin.kienzl@i-med.ac.at
Summary
Kidney retransplantation, including third and fourth transplants, offers acceptable survival rates. However, rejection remains a primary cause of graft loss in these highly sensitized patients.
Area of Science:
- Nephrology
- Transplantation Immunology
- Surgical Outcomes
Background:
- Kidney retransplantation presents higher immunological risks compared to primary transplants.
- Organ shortage and long waiting lists increase the importance of retransplantation outcomes.
- Third and fourth kidney transplants are critical for patients with end-stage renal disease.
Purpose of the Study:
- To evaluate the outcomes of third and fourth kidney retransplantations.
- To identify factors influencing patient and graft survival in retransplantation.
- To analyze the incidence of complications following third and fourth kidney transplants.
Main Methods:
- Retrospective analysis of 56 third and fourth kidney transplant cases.
- Inclusion of patient and donor demographics, operative details, and complication data.
- Assessment of surgical, immunological, and infectious complications, alongside patient and graft survival rates.
Main Results:
- Third kidney transplants showed 1- and 5-year survival rates of 97.4%/72.9% and 88.9%/53.6%, respectively.
- Fourth kidney transplants demonstrated 1- and 2-year survival rates of 84.8%/68.5% and 63.6%/47%, respectively.
- High rates of acute rejection (44% for third, 33% for fourth) and delayed graft function (49% for third, 60% for fourth) were observed.
Conclusions:
- Acceptable patient and graft survival can be achieved with third and fourth kidney transplants.
- Graft loss in this sensitized population is predominantly due to rejection.
- Intensified immunosuppression strategies may increase the risk of significant infectious complications.
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