Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Insipidus I: Introduction01:29

Diabetes Insipidus I: Introduction

Definition Diabetes insipidus is a disorder marked by the production of large amounts of dilute urine because of impaired vasopressin production, release, or kidney response. The lack of effective vasopressin action limits water reabsorption in the renal collecting ducts, which leads to excessive urinary water loss and intense thirst.Clinical PresentationIndividuals with diabetes insipidus report persistent thirst and very high urine output. In severe cases, fluid intake can reach up to 20...
Diabetes Insipidus II: Pathophysiology01:22

Diabetes Insipidus II: Pathophysiology

Normally, water balance is maintained through three interconnected mechanisms: the hypothalamic thirst center, the synthesis and release of antidiuretic hormone (ADH, or vasopressin), and the kidneys' responsiveness to this hormone. ADH is synthesized in the hypothalamus, released from the posterior pituitary, and acts on the distal nephron, allowing water reabsorption and concentrated urine production.Diabetes Insipidus and Its TypesIn diabetes insipidus (DI), this regulatory system is...
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
Urine Studies I: Urinalysis01:29

Urine Studies I: Urinalysis

Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safe resumption of Electroconvulsive therapy shortly after permanent pacemaker implantation in an elderly patient with psychotic depression: A case report and focused review of peri-procedural considerations.

Asian journal of psychiatry·2026
Same author

Recurrent catatonia: A retrospective study from North India.

Asian journal of psychiatry·2026
Same author

Management of agitation: current trends.

The lancet. Psychiatry·2026
Same author

"Does assessment method influence the prevalence of constipation in patients receiving long-term clozapine?"

Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists·2026
Same author

Resolution of Postictal Catatonia With Electroconvulsive Therapy in Temporal Lobe Epilepsy: A Rare Case Report.

The journal of ECT·2026
Same author

The impact of cardiac resynchronization therapy on diastolic parameters and mitral regurgitation: echocardiographic analysis of ultrasound-based left ventricular endocardial pacing system.

Frontiers in cardiovascular medicine·2026

Related Experiment Video

Updated: Jun 2, 2026

The Tail Suspension Test
10:17

The Tail Suspension Test

Published on: January 28, 2012

Distress due to lithium-induced polyuria: exploratory study.

Basant K Pradhan1, Subho Chakrabarti, Anand S Irpati

  • 1Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Psychiatry and Clinical Neurosciences
|May 17, 2011
PubMed
Summary
This summary is machine-generated.

Lithium treatment for bipolar disorder commonly causes polyuria (frequent urination), affecting 70% of patients. This side effect often goes unreported but significantly impacts daily life and requires medical attention.

Related Experiment Videos

Last Updated: Jun 2, 2026

The Tail Suspension Test
10:17

The Tail Suspension Test

Published on: January 28, 2012

Area of Science:

  • Nephrology
  • Psychiatry
  • Pharmacology

Background:

  • Lithium is a cornerstone treatment for bipolar disorder.
  • Lithium-induced polyuria is a known but often underreported side effect.
  • The impact of polyuria on patients' quality of life is not fully understood.

Purpose of the Study:

  • To investigate the prevalence of polyuria in patients with bipolar disorder on long-term lithium therapy.
  • To assess the associated distress and functional impairment caused by polyuria.
  • To determine the underreporting of polyuria symptoms.

Main Methods:

  • A cohort of 56 patients with bipolar disorder on long-term lithium treatment was studied.
  • Participants underwent 24-hour urine collection to measure urine volume.
  • Renal function tests were conducted to evaluate kidney health.

Main Results:

  • Polyuria, defined as >3 L of urine in 24 hours, was diagnosed in 70% of the study participants.
  • Polyuria was significantly underreported by patients unless specifically asked about.
  • Increased 24-hour urine volume correlated with reported impairments in work and daily activities.

Conclusions:

  • Lithium-induced polyuria is highly prevalent in patients with bipolar disorder.
  • Polyuria is a distressing and functionally impairing side effect that requires clinical attention.
  • Proactive inquiry about polyuria symptoms is crucial for effective patient management.