Related Experiment Video

Updated: Jun 2, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

Epidermal growth factor receptor as a therapeutic target in veterinary oncology

G T Bergkvist1, D A Yool

  • 1Royal (Dick) School of Veterinary Studies and Roslin Institute, Division of Veterinary Clinical Sciences, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian, UK. g.t.bergkvist@sms.ed.ac.uk

Veterinary and Comparative Oncology
|May 17, 2011
PubMed

Insights

Epidermal growth factor receptor (EGFR) dysregulation drives human cancers and may impact animal tumors. Further research is needed to confirm EGFR

Area of Science:

  • Oncology
  • Molecular Biology
  • Comparative Pathology

Background:

  • Epidermal growth factor receptor (EGFR) is a key driver of cell proliferation and survival, frequently dysregulated in human solid tumors.
  • EGFR is a validated therapeutic target and prognostic/predictive marker in human oncology.
  • Emerging evidence suggests EGFR dysregulation may play a role in naturally occurring animal cancers, mirroring human diseases.

Purpose of the Study:

  • To explore the role of EGFR dysregulation in animal cancers.
  • To assess the potential of EGFR as a prognostic or biological marker in veterinary oncology.
  • To highlight the need for veterinary clinical trials targeting EGFR.

Main Methods:

  • Comparative analysis of EGFR's role in human and animal cancers.
  • Review of existing literature on EGFR in naturally occurring animal tumors.
  • Identification of knowledge gaps regarding EGFR's oncogenic role in animals.

Main Results:

  • EGFR dysregulation is implicated in various animal cancers, including mammary, lung, glial, and epithelial types.
  • Animal cancers with EGFR involvement share similarities with human counterparts.
  • Direct evidence for EGFR as a critical oncogenic driver in animal disease is limited.

Conclusions:

  • EGFR is a potential prognostic and biological marker for animal diseases.
  • Establishing EGFR's critical oncogenic role in animals requires further investigation.
  • Veterinary trials of EGFR-targeted therapies are essential for advancing veterinary oncology.

More Related Videos

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library07:32

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include: