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Related Concept Videos

Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...
Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
Penis01:29

Penis

The penis serves a dual role in sexual reproduction and urination. It consists of three main regions: the glans penis, the body, and the root, each with distinct functions and unique anatomical features.
Anatomy of the Penis
The glans penis, or the head, is the terminal part of the penis and houses the external urethral orifice, the exit point for urine and semen. Covered by the prepuce, or foreskin, the glans is noted for its sensitivity and plays a key role in sexual pleasure. The body of the...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...

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Related Experiment Video

Updated: Jun 2, 2026

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
08:03

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents

Published on: June 6, 2018

9-hydroxycanthin-6-one induces penile erection and delays ejaculation.

Wen-Fei Chiou1, Tian-Shung Wu

  • 1National Research Institute of Chinese Medicine, Taipei, Taiwan.

The Journal of Sexual Medicine
|May 17, 2011
PubMed
Summary

9-hydroxycanthin-6-one, a compound from Eurycoma longifolia, enhances male sexual function by relaxing corpus cavernosum and seminal vesicle smooth muscles. This action, likely through calcium channel interference, supports its aphrodisiac reputation.

Related Experiment Videos

Last Updated: Jun 2, 2026

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
08:03

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents

Published on: June 6, 2018

Area of Science:

  • Pharmacology
  • Ethnobotany
  • Urology

Background:

  • Eurycoma longifolia Jack (Simaroubaceae) is traditionally used as a male aphrodisiac to enhance sexual performance.
  • The specific compounds responsible for its aphrodisiac effects and their mechanisms of action on sexual organs remain largely unknown.

Purpose of the Study:

  • To investigate the effects of 9-hydroxycanthin-6-one (9-HC-6-one), a β-carboline alkaloid from E. longifolia, on penile erection and ejaculation.
  • To elucidate the underlying mechanism of action of 9-HC-6-one on the corpus cavernosum (CC) and seminal vesicle (SV).

Main Methods:

  • In vitro studies on isolated rat CC and SV to assess smooth muscle relaxation.
  • In vivo studies measuring intracavernosal pressure (ICP) after intracorporal (IC) injection and intraluminal pressure (ILP) of the SV after hypogastric nerve stimulation (HNS).
  • Assessment of the involvement of nitric oxide/cyclic guanosine monophosphate (cGMP) pathways and calcium channels.

Main Results:

  • 9-HC-6-one significantly relaxed phenylephrine (PE)-precontracted CC and SV, independent of the nitric oxide pathway.
  • The compound inhibited calcium influx through voltage-dependent channels and attenuated intracellular calcium release, indicating a dual mechanism for smooth muscle relaxation.
  • IC injection of 9-HC-6-one increased ICP, and it dose-dependently reduced HNS-evoked ILP in the SV.

Conclusions:

  • 9-HC-6-one may be the active component responsible for the aphrodisiac properties of E. longifolia.
  • Its mechanism involves antagonizing the smooth muscle tone of both the CC and SV, primarily by interfering with calcium mobilization.
  • This compound shows potential for treating erectile dysfunction and related sexual disorders.