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Microsomal oxidative damage promoted by acetaminophen metabolism

María Eugenia Letelier1, Miguel López-Valladares, Liliana Peredo-Silva

  • 1Laboratory of Pharmacology and Toxicology, Department of Pharmacological and Toxicological Chemistry, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago 8380492, Chile. mel@ciq.uchile.cl

Toxicology in Vitro : an International Journal Published in Association with BIBRA
|May 17, 2011
PubMed
Summary

Acetaminophen adverse reactions linked to oxidative stress may stem from NAD(P)H oxidase (NOX) activity, not just cytochrome P450. NOX inhibitors blocked reactive oxygen species generation, suggesting NOX as a primary driver.

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