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Updated: Jun 2, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Urinary calcium response to high dose vitamin D3 with calcium supplementation in patients with multiple sclerosis
Samantha M Kimball1, Jodie M Burton, Paul G O'Connor
1University of Toronto, Department of Nutritional Sciences and Mount Sinai Hospital, Department of Pathology & Laboratory Medicine, Toronto, ON, Canada M5G 1X5. samantha.kimball@utoronto.ca
Objective:
To characterize the effect of vitamin D(3) intake on urinary calcium:creatinine ratios across predefined ranges of serum 25(OH)D.
Design:
Patients with multiple sclerosis (n=25) received escalating doses of vitamin D(3) (4000-40,000IU/d) with calcium (1200mg/d).
Results:
Urinary calcium:creatinine was driven by increased 25(OH)D when concentrations were <75nmol/L (r=0.424, p=0.009) and >200nmol/L (r=0.281, p=0.01), but no relationship existed when 25(OH)D concentrations were 76-200nmol/L.
Conclusions:
A "safe", physiological range of 25(OH)D concentrations is 75-200nmol/L.
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