Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Population Genetics?01:25

What is Population Genetics?

A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.While some alleles of a given gene might be observed commonly, other variants...
Genetic Variation01:25

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Genetic Lingo01:11

Genetic Lingo

Overview
Hardy-Weinberg Principle01:49

Hardy-Weinberg Principle

Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.In the early 20th century,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A cell surface transporter mediates phenanthridine resistance in African trypanosomes.

npj antimicrobials and resistance·2026
Same author

Elimination of gambiense human African trypanosomiasis as a public health problem in Republic of Guinea: Paving the way for zero transmission.

PLoS neglected tropical diseases·2026
Same author

The genome sequence of the nematode <i>Ostertagia ostertagi</i> (Stiles, 1892) (Rhabditida, Trichostrongylidae).

Wellcome open research·2026
Same author

UTILIZING THE POWER OF PUBLIC ENGAGEMENT IN PARASITOLOGY: A RETROSPECTIVE.

The Journal of parasitology·2026
Same author

Monkeypox Virus Antibodies in Healthy Persons after Vaccination with MVA-BN, United Kingdom.

Emerging infectious diseases·2026
Same author

Trypanosoma brucei cattle infections contain cryptic transmission-adapted bloodstream forms at low parasitaemia.

Nature communications·2025

Related Experiment Video

Updated: Jun 2, 2026

Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model
08:20

Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model

Published on: October 27, 2023

Trypanosome genetics: populations, phenotypes and diversity.

Andy Tait1, Liam J Morrison, Craig W Duffy

  • 1Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom. a.tait@vet.gla.ac.uk

Veterinary Parasitology
|May 17, 2011
PubMed
Summary

African trypanosome genotypic diversity is shaped by genetic exchange mechanisms. Understanding parasite and host diversity is crucial for deciphering infection outcomes, especially for traits like virulence and drug resistance.

More Related Videos

A Multi-detection Assay for Malaria Transmitting Mosquitoes
09:00

A Multi-detection Assay for Malaria Transmitting Mosquitoes

Published on: February 28, 2015

High-throughput Gene Tagging in Trypanosoma brucei
11:26

High-throughput Gene Tagging in Trypanosoma brucei

Published on: August 12, 2016

Related Experiment Videos

Last Updated: Jun 2, 2026

Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model
08:20

Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model

Published on: October 27, 2023

A Multi-detection Assay for Malaria Transmitting Mosquitoes
09:00

A Multi-detection Assay for Malaria Transmitting Mosquitoes

Published on: February 28, 2015

High-throughput Gene Tagging in Trypanosoma brucei
11:26

High-throughput Gene Tagging in Trypanosoma brucei

Published on: August 12, 2016

Area of Science:

  • Molecular biology
  • Population genetics
  • Parasitology

Background:

  • Extensive research has explored African trypanosome genotypic diversity using molecular markers.
  • Population genetic analysis has elucidated mechanisms generating this diversity.

Purpose of the Study:

  • To review current understanding of African trypanosome diversity and its generating mechanisms.
  • To update knowledge on genetic exchange in Trypanosoma brucei.
  • To highlight under-researched areas of phenotypic variation.

Main Methods:

  • Review of molecular marker studies.
  • Population genetic analysis.
  • Laboratory analysis of genetic exchange in Trypanosoma brucei.

Main Results:

  • Genetic exchange in Trypanosoma brucei is well-characterized and can dissect phenotypic traits.
  • Phenotypic variation exists in tsetse transmission, virulence, and blood-brain barrier crossing.
  • A locus for organomegaly in Trypanosoma brucei has been identified.

Conclusions:

  • Integrating host and parasite diversity studies is essential for understanding infection outcomes.
  • Further research is needed on the genetic basis of phenotypic variation beyond drug resistance.