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Updated: Jun 2, 2026

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

A novel method for designing and fabricating custom-made artificial bones.

H Saijo¹, Y Kanno, Y Mori

¹Department of Oral and Maxillofacial Surgery, Faculty of Medicine, The University of Tokyo, Japan. saijyoh-ora@h.u-tokyo.ac.jp

International Journal of Oral and Maxillofacial Surgery

|May 17, 2011

Summary

This study introduces a new method for creating custom artificial bones using 3D printing and radiopaque wax. This technique offers improved customization for patients with facial deformities, enhancing reconstructive surgery outcomes.

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Area of Science:

Biomaterials Science
Medical Imaging
Computer-Aided Design

Background:

Artificial bones are crucial for tissue augmentation in patients with facial deformities.
Current custom bone fabrication methods using computer-aided design (CAD) have limitations in recreating intricate details.
Existing techniques may not fully meet the unique anatomical requirements of individual patients.

Purpose of the Study:

To develop an improved method for designing patient-specific artificial bones.
To enhance the customization and accuracy of artificial bone fabrication for reconstructive surgery.
To address the limitations of conventional CAD-based mirroring techniques.

Main Methods:

Utilized computed tomography (CT) data to create three-dimensional (3D) simulation models via inkjet printing with plaster.
Applied a specially formulated radiopaque paraffin wax containing a contrast medium to the 3D models to define target structures.
Re-scanned the wax-enhanced models using CT to capture precise target structure data for fabrication.
Fabricated the final artificial bones using an inkjet printer based on the detailed CT data.

Main Results:

The novel technique allows for the creation of artificial bones with greater customization compared to traditional methods.
The use of radiopaque wax enabled precise definition and imaging of target structures for accurate fabrication.
The fabricated artificial bones demonstrated a better fit and met individual patient requirements more effectively.

Conclusions:

The developed method offers a more sophisticated approach to designing patient-specific artificial bones.
This technique shows promise for improving aesthetic and functional outcomes in reconstructive surgery for facial deformities.
Further consideration of soft tissue status is recommended for optimal aesthetic results in conjunction with this method.