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Macrolactin W, a new antibacterial macrolide from a marine Bacillus sp
M A Mojid Mondol1, Ji Hye Kim, Hyi-Seung Lee
1Marine Natural Products Chemistry Laboratory, Korea Ocean Research & Development Institute, Ansan, Seoul, Republic of Korea.
Abstract:
Bioactivity-guided isolation for the new/novel metabolites from the EtOAc extract obtained from the culture broth of a marine Bacillus sp. 09ID194 followed by chromatographic fractionations and subsequently HPLC purifications led to the isolation of two known macrolides, macrolactins A (1) and Q (2), together with a new glycosylated marcrolide, macrolactin W (3). The chemical structures of compounds 1-3 were assigned based on extensive MS and NMR spectral data analysis and literature review. Compound 3 showed potent antibacterial activity against both Gram-positive and Gram-negative pathogenic bacteria.
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