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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

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Updated: Jun 2, 2026

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

New pharmaceutical applications for macromolecular binders.

Nicolas Bertrand1, Marc A Gauthier, Céline Bouvet

  • 1Faculty of Pharmacy, Université de Montréal, PO Box 6128, Downtown Station, Montréal, Québec H3C 3J7, Canada. nicolas.bertrand@umontreal.ca

Journal of Controlled Release : Official Journal of the Controlled Release Society
|May 17, 2011
PubMed
Summary
This summary is machine-generated.

Macromolecular binders, including polymers and dendrimers, offer new therapeutic strategies by binding to various substrates. Their clinical success highlights their potential in host/guest chemistry and pharmacology.

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Last Updated: Jun 2, 2026

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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Area of Science:

  • Host/Guest Chemistry
  • Pharmacology
  • Polymer Science

Background:

  • Macromolecular binders are polymers, dendrimers, and oligomers designed to bind endogenous or exogenous substrates.
  • The field has experienced a resurgence due to successful clinical applications of sequestrants like sevelamer hydrochloride and sugammadex.
  • Multivalent binding by these agents can alter substrate properties, affecting biological interactions and responses.

Purpose of the Study:

  • To review the current state-of-the-art in macromolecular binder technology.
  • To provide examples of recent advancements and their pharmaceutical potential.
  • To explore the application of macromolecular binders across a range of substrate sizes, from ions to cells.

Main Methods:

  • Literature review of recent developments in macromolecular binder research.
  • Analysis of clinical successes and ongoing pharmaceutical applications.
  • Categorization of binders based on substrate size and binding mechanisms.

Main Results:

  • Demonstrated success of macromolecular sequestrants in clinical settings.
  • Identification of diverse applications for macromolecular binders, targeting substrates from small molecules to biological entities.
  • Highlighting promising future pharmaceutical applications based on current research.

Conclusions:

  • Macromolecular binders represent a significant area of innovation at the intersection of chemistry and medicine.
  • Their ability to modulate substrate interactions offers broad therapeutic potential.
  • Continued research promises novel pharmaceutical solutions for various medical conditions.