Coordinating migratory neuron polarization by numb-ing communication
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Updated: Jun 2, 2026

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures
Published on: April 21, 2011
Joshua J Breunig1, Pasko Rakic
1Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
Abstract:
An interplay between intrinsic polarity and extracellular cues guides neuronal migration during cerebellar development. In this issue of Developmental Cell, Zhou et al. (2011) demonstrate that Numb is the focal point in mediating the chemotactic response of migrating cerebellar granule cells to BDNF through its regulation of cell polarity.
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