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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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Interventions that induce modifications in the tumor microenvironment.

E J Bernhard1

  • 1Radiotherapy Development Branch, Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute/National Institutes of Health, 6130 Executive Boulevard, Rockville, MD 20892-7440, United States. bernhardej@mail.nih.gov

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|May 17, 2011
PubMed
Summary
This summary is machine-generated.

This review explores how the tumor microenvironment impacts cancer therapies. Understanding these interactions offers new therapeutic opportunities beyond direct cancer cell killing.

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Area of Science:

  • Oncology
  • Cancer Biology
  • Immunology

Background:

  • Traditional cancer therapies like chemotherapy and radiation primarily aim to directly eliminate cancer cells.
  • Emerging evidence highlights the significant role of the tumor microenvironment (TME) in modulating treatment efficacy.
  • The TME presents complex challenges and novel avenues for therapeutic development.

Purpose of the Study:

  • To review current understanding of the tumor microenvironment's influence on non-surgical cancer therapies.
  • To identify obstacles and opportunities within the TME for novel therapeutic strategies.
  • To discuss recent advancements in targeting the TME for improved cancer treatment.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of research on cellular and non-cellular components of the TME.
  • Synthesis of findings related to therapeutic resistance and sensitivity influenced by the TME.

Main Results:

  • The TME, comprising various cells and extracellular matrix components, significantly affects treatment outcomes.
  • Specific TME characteristics can promote therapeutic resistance or enhance sensitivity.
  • Targeting the TME offers potential to overcome limitations of conventional therapies.

Conclusions:

  • The tumor microenvironment is a critical determinant of non-surgical cancer therapy success.
  • Modulating the TME presents a promising strategy for developing more effective cancer treatments.
  • Future research should focus on TME-targeted therapies to improve patient outcomes.