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Related Experiment Video

Updated: Jun 2, 2026

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

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Published on: July 4, 2017

Growth hormone can decrease muscle damage complication in tibia lengthening by external fixation.

Sang Eun Park¹, Pan Kun Park

¹Department of Orthopaedic Surgery, Dongguk University International Hospital, Ilsan, Korea. pse0518@duih.org

Journal of Pediatric Orthopedics

|May 17, 2011

Summary

Growth hormone (GH) administration mitigates muscle damage during limb lengthening procedures. GH treatment enhanced muscle regeneration and reduced fibrogenesis in lengthened limbs, preserving muscle function.

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Area of Science:

Orthopedics
Endocrinology
Regenerative Medicine

Background:

Limb lengthening procedures can cause significant muscle damage and functional impairment.
Growth hormone (GH) plays a crucial role in tissue growth and repair, but its effects on muscle during limb lengthening are not fully understood.

Purpose of the Study:

To investigate the impact of growth hormone (GH) on muscle tissue during tibial lengthening in a rat model.
To assess GH's potential to reduce muscle damage and enhance muscle regeneration.

Main Methods:

Tibial lengthening was performed on 60 rats, with 30 receiving recombinant GH and 30 receiving saline.
Histopathological, immunohistochemical (vimentin, proliferating cell nuclear antigen, desmin), and electrophysiological analyses were conducted on the tibialis anterior muscle.

Main Results:

GH-treated lengthened limbs showed reduced muscle injury and lower vimentin expression compared to saline-treated limbs.
Cell proliferation (PCNA staining) and desmin expression were highest in GH-treated lengthened limbs, indicating enhanced myogenesis.
Electrophysiological studies demonstrated better muscle function retention in GH-treated lengthened limbs.

Conclusions:

Growth hormone (GH) effectively reduces muscle damage associated with limb lengthening.
GH promotes myogenesis and decreases fibrogenesis, thereby improving muscle outcomes during limb lengthening procedures.