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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
05:05

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Conjunctival erosions associated with pemphigus vulgaris

Rachel Brackley1, Jean Marie Pagani

  • 1The Eye Institute at Pennsylvania College of Optometry at Salus University, Philadelphia, Pennsylvania, USA.

Optometry and Vision Science : Official Publication of the American Academy of Optometry
|May 17, 2011
PubMed
Abstract

Insights

Ocular pemphigus vulgaris (PV) involves the eyes and is often underdiagnosed. Early diagnosis and multidisciplinary treatment are crucial for managing this rare autoimmune condition.

Area of Science:

  • Ophthalmology
  • Dermatology
  • Autoimmunology

Background:

  • Pemphigus vulgaris (PV) is a rare autoimmune blistering disease affecting skin and mucous membranes.
  • Ocular involvement in PV is uncommon but can indicate severe systemic disease.

Observation:

  • A case of a 43-year-old female with a 20-year history of systemic PV presenting with ocular symptoms.
  • Clinical examination revealed conjunctival hyperemia and erosion in the left eye.

Findings:

  • Diagnosis of ocular PV was made based on clinical presentation and patient history.
  • The case highlights the importance of recognizing ocular manifestations of PV.

Implications:

  • Ocular PV requires prompt diagnosis and a multidisciplinary approach involving ophthalmologists and dermatologists.
  • Management focuses on treating ocular lesions and controlling the underlying systemic autoimmune condition.

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