[99mTc-MAG3 and 131I-OIH in patients with kidney insufficiency and with normal kidneys]

Renal clearance of 99mTc-mercaptoacetyltriglycine (MAG3) and 131J-orthoidohippurate (OIH) were compared by simultaneous measurement in 50 patients. Renal time-activity-curves of both radiopharmaceuticals were compared in 50 patients. With regard to the clearance, good correlation (r = 0.95) with a mean ratio MAG3-/OIH-clearance of 0.62 was found. No significant difference between patients with normal (n = 30) and impaired (n = 20) renal function could be demonstrated. Renal time activity curves and relative renal function showed good correspondence in patients with normal (n = 13) and impaired (n = 7) renal function. It is concluded that MAG3 may be used as substitute for OIH in patients with normal and impaired renal function.