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[Transcranial Doppler sonography. Normal values and physiologic changes].

K Rosenkranz1, R Langer, R Felix

  • 1Radiologische Klinik und Poliklinik, Universitätsklinikum Rudolf Virchow, Standort Charlottenburg, Freie Universität Berlin.

Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin
|March 1, 1990
PubMed
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This study established age-dependent reference values for cerebral artery blood flow velocity and pulsatility index using transcranial Doppler ultrasound in 100 healthy adults. Findings reveal significant age-related changes in these key cerebrovascular parameters.

Area of Science:

  • Neurosonology
  • Cerebrovascular physiology
  • Medical imaging

Context:

  • Establishing normative data for cerebral blood flow is crucial for diagnosing various neurological conditions.
  • Transcranial Doppler (TCD) ultrasound is a non-invasive tool for assessing cerebral hemodynamics.
  • Age is a known factor influencing vascular parameters, necessitating age-specific reference ranges.

Purpose:

  • To determine age-dependent reference values for mean flow velocity (MFV) and mean pulsatility index (PI) in the middle (MCA), anterior (ACA), and posterior (PCA) cerebral arteries.
  • To analyze variations in these parameters with increasing age.
  • To investigate the influence of ventilation and cardiac function on cerebral hemodynamics.

Summary:

  • Mean flow velocity and pulsatility index in the MCA, ACA, and PCA were measured in 100 healthy subjects using TCD ultrasound.

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  • Significant age-related variations were observed, with increasing PI and decreasing MFV noted with advancing age.
  • MCA exhibited the highest MFV, PCA the lowest, and ACA showed the greatest inter-side difference. Ventilation and cardiac function also impacted measured parameters.

    • Impact:

    • Provides essential age-specific reference ranges for interpreting TCD ultrasound findings in clinical practice.
    • Enhances the diagnostic accuracy for cerebrovascular diseases and monitoring therapeutic interventions.
    • Contributes to a better understanding of age-related physiological changes in cerebral circulation.