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Published on: December 7, 2012
In vitro function of random donor platelets stored for 7 days in composol platelet additive solution
Ashish Gupta1, Tulika Chandra, Ashutosh Kumar
1Department of Transfusion Medicine and Blood Bank, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India.
Asian Journal of Transfusion Science
|May 17, 2011
Summary
Storing random donor platelets in additive solution for 7 days at 22°C maintains their in vitro function. This extended shelf life for platelet additive solution storage can improve platelet availability.
Area of Science:
- Hematology
- Transfusion Medicine
Background:
- Platelets are typically stored for 5 days.
- Current storage methods limit platelet availability.
Purpose of the Study:
- To assess the in vitro function of random donor platelets stored for 7 days.
- To evaluate the efficacy of platelet additive solution for extended storage.
Main Methods:
- 30 donors provided whole blood.
- Platelets were isolated using the platelet-rich plasma method.
- Stored for 7 days at 22°C with and without additive solution.
Main Results:
- Platelet swirling observed on day 7, with no bacterial contamination.
- Additive solution maintained platelet count, lactate dehydrogenase, and pH.
- Platelet factor 3, glucose, and aggregation were significantly better preserved with additive solution.
Conclusions:
- Platelet viability and aggregation are best maintained for 7 days in additive solution at 22°C.
- Extended shelf life of 7 days using additive solution is feasible.
- This approach can enhance the inventory of available platelets.
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