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Cohesins02:20

Cohesins

Cohesin protein complexes are a molecular glue that holds two sister chromatids together. They play an important role both in mitosis and meiosis. In mitosis, all cohesin complexes present on the chromosomes are removed before the start of the anaphase stage.
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Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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The Retinoblastoma Gene01:20

The Retinoblastoma Gene

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The Retinoblastoma Gene

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Pleiotropy

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New Multicomponent Crystals of Antidiabetic Drug, Metformin: Mechanochemistry, Structural Studies, Biological Activity and Topological Analysis.

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"Eye-Conic" Spatial Transcriptomics Reveals the Layer-Specific Molecular Alterations in Corneas of Patients With Keratoconus.

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Related Experiment Video

Updated: Jun 2, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

The genetics of keratoconus.

Dorota M Nowak1, Marzena Gajecka

  • 1Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland, Strzeszynska 32, 60-479 Poznan.

Middle East African Journal of Ophthalmology
|May 17, 2011
PubMed
Summary

Keratoconus (KTCN) is a corneal condition influenced by genetics and environment. Research is exploring genetic factors and using bioinformatics to identify genes involved in this vision-impairing disorder.

Area of Science:

  • Ophthalmology
  • Genetics
  • Bioinformatics

Background:

  • Keratoconus (KTCN) is a non-inflammatory corneal disease characterized by thinning and protrusion.
  • It leads to distorted vision and altered refractive error.
  • KTCN is a complex condition with multifactorial causes, including genetic and environmental factors.

Purpose of the Study:

  • To focus on the genetic aspects of keratoconus etiology.
  • To discuss the application of bioinformatics in identifying genes associated with KTCN.

Main Methods:

  • Review of evidence for genetic etiology in KTCN, including familial inheritance and twin studies.
  • Discussion of mapped genetic loci for familial KTCN.
  • Exploration of bioinformatics methodologies used in gene identification for KTCN.
Keywords:
GeneticsKeratoconusKeratoconus Loci

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Published on: October 21, 2022

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Last Updated: Jun 2, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

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Published on: November 12, 2015

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
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Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

Main Results:

  • Several loci linked to familial KTCN have been identified.
  • No specific gene mutations have been confirmed for these loci to date.
  • Bioinformatics approaches are crucial for advancing gene discovery in KTCN.

Conclusions:

  • Genetic factors play a significant role in the development of keratoconus.
  • Further research utilizing advanced bioinformatics is necessary to pinpoint specific genes responsible for KTCN.
  • Understanding the genetic basis of KTCN is key to developing targeted therapies.