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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Ocular surface squamous neoplasia masquerading as superior limbic keratoconjunctivitis
Majid Moshirfar1, Yousuf M Khalifa, Annie Kuo
1Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
Middle East African Journal of Ophthalmology
|May 17, 2011
Summary
Ocular surface squamous neoplasia (OSSN) can mimic superior limbic keratoconjunctivitis (SLK). This case highlights the importance of biopsy for refractory ocular surface lesions to rule out malignancy.
Area of Science:
- Ophthalmology
- Oncology
Background:
- Superior limbic keratoconjunctivitis (SLK) is a chronic inflammatory condition of the ocular surface.
- Ocular surface squamous neoplasia (OSSN) is a premalignant or malignant proliferation of the conjunctiva or cornea.
Purpose of the Study:
- To report a rare case of OSSN presenting with clinical features mimicking SLK.
- To emphasize the diagnostic challenges and the importance of histopathological evaluation.
Main Methods:
- A case report of a 62-year-old woman with a 10-month history of left eye symptoms.
- Initial treatment for presumed SLK with topical corticosteroids.
- Excisional biopsy of the superior conjunctiva for definitive diagnosis.
Main Results:
- Histopathological evaluation of the biopsy revealed OSSN with moderate to marked dysplasia.
- The patient's presentation initially mimicked SLK, leading to delayed diagnosis.
- This is the first reported case of OSSN masquerading as SLK.
Conclusions:
- OSSN can present atypically, mimicking benign conditions like SLK.
- Ocular surface lesions unresponsive to standard treatment warrant further investigation, including biopsy.
- Early diagnosis and treatment of OSSN are crucial to prevent vision loss and metastasis.
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