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Related Concept Videos

Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

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Related Experiment Video

Updated: Jun 2, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Central nervous system tuberculosis.

A Cherian1, S V Thomas

  • 1Department of Neurology, Government Medical College, Trivandrum, Kerala, India, PIN-695011. drajithcherian@yahoo.com

African Health Sciences
|May 17, 2011
PubMed
Summary
This summary is machine-generated.

Tuberculous meningitis (TBM) diagnosis requires detecting Mycobacterium tuberculosis in cerebrospinal fluid. Early treatment initiation, imaging, and considering corticosteroids are crucial for better outcomes in central nervous system tuberculosis.

Keywords:
drug resistanthuman immunodeficiency virusmeningitismycobacteriumsteroids

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A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients
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A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
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A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients
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A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

Area of Science:

  • Neurology
  • Infectious Diseases
  • Pulmonology

Background:

  • Central nervous system (CNS) tuberculosis (TB) affects 5-10% of extrapulmonary TB cases.
  • Tuberculous meningitis (TBM) diagnosis relies on detecting tubercle bacilli in cerebrospinal fluid (CSF).
  • Early diagnosis and treatment are critical for managing CNS TB.

Purpose of the Study:

  • To outline diagnostic and management strategies for tuberculous meningitis (TBM).
  • To emphasize the importance of early intervention and comprehensive patient evaluation.
  • To provide guidance on drug resistance and adjunctive therapies.

Main Methods:

  • CSF analysis for Mycobacterium tuberculosis detection.
  • Contrast-enhanced CT imaging for TBM evaluation.
  • Clinical and radiological assessment for extra-neural TB foci.

Main Results:

  • Treatment duration of at least 10 months is recommended.
  • Adjunctive corticosteroids may be given at presentation, including in HIV-infected patients.
  • Drug resistance is linked to prior treatment; avoid adding single drugs to failing regimens.

Conclusions:

  • The stage of TBM at treatment initiation is the primary determinant of outcome.
  • Prompt diagnosis, appropriate imaging, and timely management are essential.
  • Consider ventriculo-peritoneal shunting for hydrocephalus unresponsive to medical management.