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PERIPHERAL MYELIN PROTEIN-22 IS EXPRESSED IN CNS MYELIN

Rita De Gasperi1, Miguel A Gama Sosa, Zuzanna Naumowicz

  • 1Research and Development, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York 10468, USA.

Translational Neuroscience
|May 17, 2011
PubMed

Insights

Peripheral myelin protein-22 (PMP-22) protein is present in the adult brain, suggesting its role in central nervous system (CNS) myelin maintenance. Altered PMP-22 expression may be relevant to schizophrenia pathophysiology.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pathophysiology

Background:

  • Schizophrenia is associated with myelin abnormalities, implicating oligodendrocyte dysfunction.
  • Decreased peripheral myelin protein-22 (PMP-22) mRNA expression in schizophrenia suggests a potential genetic link.
  • PMP-22 protein expression in the brain has been previously considered absent.

Purpose of the Study:

  • To investigate the presence and role of PMP-22 protein in adult mammalian CNS myelin.
  • To explore the pathophysiological relevance of PMP-22 in central nervous system disorders like schizophrenia.

Main Methods:

  • Isolation of myelin from adult mouse and human brain tissue.
  • Detection of PMP-22 protein within the isolated myelin.

Main Results:

  • PMP-22 protein was detected in myelin from both adult mouse and human brains.
  • This finding contradicts previous assumptions about the absence of PMP-22 protein expression in the brain.

Conclusions:

  • PMP-22 protein is likely involved in the maintenance and function of central nervous system (CNS) myelin.
  • The presence of PMP-22 protein provides a molecular basis for the link between altered PMP-22 expression and schizophrenia.

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