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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
Screening for cognitive decline following single known stroke using the Mini-Mental State Examination
David B Arciniegas1, Gregory F Kellermeyer, Nancy M Bonifer
1Brain Injury Rehabilitation Unit, HealthONE Spalding Rehabilitation Hospital, Aurora, CO, USA;
Neuropsychiatric Disease and Treatment
|May 17, 2011
Summary
The Mini-Mental State Examination (MMSE) may effectively screen for cognitive decline in stroke survivors. Normative interpretation of MMSE scores shows potential for identifying post-stroke cognitive impairment, even years after the event.
Area of Science:
- Neurology
- Cognitive Science
Background:
- Progressive cognitive decline affects a significant portion of stroke survivors.
- The Mini-Mental State Examination (MMSE) is widely used for older adults but its utility in younger stroke survivors is less clear.
Purpose of the Study:
- To evaluate the Mini-Mental State Examination (MMSE) as a screening tool for cognitive decline in a broad age range of stroke survivors.
- To determine the prevalence of cognitive impairment using normatively interpreted MMSE scores in remote stroke survivors.
Main Methods:
- Assessed 27 stroke survivors (aged 18-82) using the MMSE.
- Compared MMSE scores to population-based norms to identify cognitive impairment.
- Explored correlations between cognitive performance and factors like age, gender, and time since stroke.
Main Results:
- Mild cognitive impairment was identified in 22.2% and moderate-to-severe impairment in 7.4% of subjects using age-adjusted MMSE scores.
- MMSE scores showed an inverse correlation with time since stroke.
- No significant relationship was found between MMSE performance and motor impairments (Fugl-Meyer scores).
Conclusions:
- Normatively interpreted MMSE scores may identify cognitive decline in the late period following a single stroke.
- The severity of motor impairment does not reliably indicate the need for cognitive assessment.
- Further research with larger cohorts is recommended to confirm the MMSE's role in screening for post-stroke cognitive decline.
