Related Experiment Video
Updated: Jun 2, 2026

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
Characterization of spontaneous immunological regression in histiocytoma .2. Participation of tumor-necrosis-factor
Abstract:
Animals which reject a histiocytoma show extensive necrosis of the tumor and produce TNF in an autologus manner without any external stimulation. An excellent correlation between the expression of TNF and the levels of TNF in circulation during tumor regression is demonstrated. TNF purified from the sera of tumor regressing animals is cytotoxic to AK-5 cells in vitro. Anti TNF antibody neutralizes the cytotoxic activity of TNF against AK-5 cells in vitro. Injection of monoclonal antibodies against TNF into tumor bearing animals delays the appearance of necrosis in AK-5 tumors thereby suggesting a direct role for TNF in AK-5 rejection.
Related Concept Videos
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
The Tumor Microenvironment
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Tumor Immunotherapy
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

