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A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
Published on: December 1, 2023
Radiofrequency capacitive hyperthermia for superficial malignant-tumors
T Fujimura1, Y Yonemura, S Fushida
1KANAZAWA UNIV,SCH MED,DEPT UROL,KANAZAWA,ISHIKAWA 920,JAPAN. KANAZAWA UNIV,SCH MED,DEPT RADIOL,KANAZAWA,ISHIKAWA 920,JAPAN.
International Journal of Oncology
|May 17, 2011
Summary
Radiofrequency hyperthermia combined with chemotherapy and radiotherapy (HCR therapy) showed a 61.1% efficacy in treating inoperable cancers. Higher temperatures (≥43°C) improved treatment outcomes, suggesting HCR therapy is a viable option.
Area of Science:
- Oncology
- Medical Physics
Background:
- Inoperable head, neck, and upper chest wall cancers present significant treatment challenges.
- Combining therapies is crucial for improving outcomes in advanced malignancies.
Purpose of the Study:
- To evaluate the efficacy and safety of radiofrequency hyperthermia in combination with chemotherapy and radiotherapy (HCR therapy).
- To assess the impact of intratumoral temperature on treatment response.
Main Methods:
- Eighteen patients with inoperable cancers received HCR therapy.
- Maximal intratumoral temperatures were monitored and correlated with response.
- Adverse events, such as heat burns, were recorded.
Main Results:
- Overall efficacy (%CR+PR) was 61.1% (3 complete responses, 8 partial responses).
- Efficacy was significantly higher (71%) when maximal intratumoral temperature reached ≥43°C compared to <43°C (25%).
- Eight patients experienced heat burns, all resolved with conservative therapy.
Conclusions:
- HCR therapy demonstrates potential utility in treating inoperable superficial malignant tumors.
- Achieving higher intratumoral temperatures is associated with improved treatment efficacy.
- HCR therapy is generally well-tolerated, with skin burns being manageable.
