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Histamine H3 receptor agonists decrease hypothalamic histamine levels and increase stereotypical biting in mice

Junichi Kitanaka1, Nobue Kitanaka, F Scott Hall

  • 1Department of Pharmacology, Hyogo College of Medicine, Hyogo 663-8501, Japan. kitanaka-hyg@umin.net

Neurochemical Research
|May 17, 2011
PubMed
Summary
This summary is machine-generated.

Histamine H(3) receptor agonists, including (R)-α-methylhistamine, imetit, and immepip, altered methamphetamine-induced behaviors in mice. These agonists shifted behaviors from sniffing to biting, potentially by modulating hypothalamic histamine levels.

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Area of Science:

  • Neuropharmacology
  • Behavioral Neuroscience

Background:

  • Methamphetamine (METH) induces stereotypical behaviors, including sniffing and biting, in animal models.
  • Histamine plays a role in modulating neurotransmission and behavior.

Purpose of the Study:

  • To investigate the effects of histamine H(3) receptor agonists on methamphetamine-induced stereotypical behaviors in mice.
  • To explore the potential role of hypothalamic histamine levels in mediating these behavioral changes.

Main Methods:

  • Male ddY mice were administered methamphetamine (10 mg/kg) to induce stereotypical behaviors.
  • Mice were pretreated with histamine H(3) receptor agonists: (R)-α-methylhistamine, imetit, or immepip.
  • Stereotypical behaviors were quantified, and hypothalamic histamine levels were measured.

Main Results:

  • Methamphetamine administration induced significant sniffing and biting behaviors.
  • (R)-α-methylhistamine dose-dependently decreased sniffing and increased biting.
  • Imetit and immepip mimicked the effects of (R)-α-methylhistamine.
  • Histamine H(3) receptor agonists reduced the METH-induced increase in hypothalamic histamine levels.

Conclusions:

  • Histamine H(3) receptor agonists can modulate methamphetamine-induced behaviors.
  • The observed behavioral shift from sniffing to biting may be mediated by the regulation of hypothalamic histamine levels.