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Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency
Published on: February 2, 2024
A case of prostatic adenocarcinoma with Paneth cell-like appearance
Yasuhiro Nakamura1, Fumiyoshi Fujishima, Mika Watanabe
1Department of Pathology, Tohoku University School of Medicine, Sendai, Japan. yasu-naka@patholo2.med.tohoku.ac.jp
Abstract:
Paneth cell-like appearance of prostatic carcinoma cells with eosinophilic cytoplasmic granules is rarely reported, and is known to be associated with neuroendocrine differentiation of carcinoma cells. We report a case of prostatic adenocarcinoma with Paneth cell-like appearance that was localized next to conventional adenocarcinoma, and demonstrate its neuroendocrine differentiation by using immunohistochemical analysis. Paneth cell-like appearance of prostatic carcinoma cells should be recognized and considered as a sign of neuroendocrine differentiation due to the possible association with resistance to hormone therapy.
