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Drug targeting: anti-HSV-1 activity of mannosylated polymer-bound 9-(2-phosphonylmethoxyethyl)adenine
1Département de Biochimie des Glycoconjugués et Lectines Endogènes, CNRS, INSERM, Orléans, France.
Biochemical and Biophysical Research Communications
|March 30, 1990
Abstract:
The antiviral drug, 9-(2-phosphonylmethoxyethyl) adenine (PMEA) was linked to a synthetic and neutral polymer bearing mannosyl residues to allow its internalization by macrophages via membrane lectins. PMEA bound to the mannosylated polymer was more efficient in vitro than free PMEA in preventing lysis of human macrophages by herpes virus.