Related Experiment Video
Updated: Jun 2, 2026

Isolation and Compositional Analysis of Plant Cuticle Lipid Polyester Monomers
Published on: November 22, 2015
[Synthesis of heptakis(2,3,6-tri-O-methoxymethyl)-beta-cyclodextrin and its application in gas chromatography]
Mingming Yin1, Xiaobo Zhu, Yongliang Liu
1Key Laboratory of Pesticide Chemistry and Application Technology of Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Abstract:
A new chiral stationary phase for gas chromatography, heptakis (2, 3, 6-tri-O-methoxymethyl)-beta-cyclodextrin, was synthesized by substituting the 2,3,6-OH groups of beta-cyclodextrin with methoxymethyl groups, and a coated capillary column for gas chromatography was made by coating this new stationary phase with static method. The chromatographic properties and separation abilities of the prepared stationary phase were studied. The test results showed that it possessed good separation abilities to Grob test mixture, disubstituted benzene isomers (e. g. nitrotoluenes, bromotoluenes, dichlorobenzenes, dimethylbenzenes) and some chiral compounds such as methyl 2-hydroxypropionates, ethyl 2-hydroxypropionates, methyl 2-methylsulfonylpropionates. The comparison of chiral separation results between 2,3,6-tri-O-methoxymethyl-beta-cyclodextrin and 2,3,6-tri-O-methyl-beta-cyclodextrin showed that the separation abilities of the two stationary phases were different and complementary to each other for some chiral ester enantiomers.
Related Concept Videos
Gas Chromatography: Introduction
In GC, a sample is vaporized and mixed with an inert carrier gas (the mobile phase), which transports it through a column.
Gas Chromatography–Mass Spectrometry (GC–MS)
A gas chromatograph consists of a long, narrow capillary column with a polysiloxane coating on the inner wall. The coating...
Gas Chromatography: Types of Columns and Stationary Phases
For an analyte to remain on the column for a sufficient amount of time, it must exhibit some level of compatibility (or...
Supercritical Fluid Chromatography
SFC utilizes a supercritical fluid mobile phase,...
Gas Chromatography: Sample Injection Systems
Two primary injection methods are used...
Gas Chromatography: Types of Detectors-I
TCD is the earliest and most widely used detector that operates by measuring the changes in the thermal conductivity of the carrier gas. When a sample compound enters the detector,...

