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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

[Enterovirus infection as a risk factor of acute coronary syndrome and its complications]

V Ia Plotkin, V L Voronel', M A Timoshina

    Klinicheskaia Meditsina
    |May 18, 2011
    PubMed

    Insights

    Enterovirus infection is a key factor in acute coronary syndrome (ACS), directly contributing to its pathogenesis. This viral presence promotes the development of severe complications like cardiogenic shock and cardiac rupture in patients.

    Area of Science:

    • Cardiology
    • Virology
    • Pathogenesis

    Context:

    • Acute coronary syndrome (ACS) encompasses conditions like myocardial infarction (MI) and unstable angina (UA).
    • Cardiogenic shock and cardiac rupture are severe, often fatal, complications of MI.
    • The role of viral infections, specifically enteroviruses, in ACS pathogenesis is an area of ongoing research.

    Purpose:

    • To quantitatively detect enterovirus antigens in patients with ACS.
    • To investigate the correlation between enterovirus antigen levels and the severity of ACS, including complications like cardiogenic shock and cardiac rupture.
    • To determine if enterovirus infection is a contributing factor to ACS and its severe outcomes.

    Summary:

    • Enterovirus antigens were detected in blood (49%), coronary artery (95.8%), and heart tissues (54.3%) of ACS patients.
    • Elevated relative levels of enterovirus antigen in blood (RLEVA) were observed in patients with MI, particularly those with cardiogenic shock/cardiac rupture, compared to UA patients.
    • Higher RLEVA was found in necrotized myocardial areas and associated coronary vessels in patients with MI complicated by cardiogenic shock/cardiac rupture.

    Impact:

    • Enterovirus infection is identified as a significant factor in ACS.
    • The findings suggest direct involvement of enteroviruses in the pathogenesis of ACS.
    • Enterovirus infection appears to promote the development of cardiogenic shock and/or cardiac rupture, highlighting potential therapeutic targets.

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