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[Platelet adrenergic alpha receptors in hypertensive subjects undergoing treatment with calcium antagonists]
A Radaelli1, A Caporotondi, C Muggia
1Dipartimento di Medicina Interna e Terapia medica, Università di Pavia.
Abstract:
The effects of two different calcium-channel blocking agents on platelet alpha-2 adrenoceptors were studied in 18 mild to moderate hypertensive patients. The subjects were randomly assigned in a double blind fashion to treatment with either nifedipine 10 mg t.i.d. or tiapamil 300 b.i.d. for six weeks. Platelet alpha-2 receptors were studied before and following 6 weeks of treatment using radioligand binding assay (3H Rauwolscine). Both agents induced a reduction in alpha-2 receptors, which reached statistical significance only for nifedipine. Such a reduction may contribute to the antihypertensive effect of calcium-channel blocking drugs.