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Updated: Jun 2, 2026

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
Decline in tuberculosis with 19 years of universal directly observed therapy in a comprehensive statewide program
R M Webb1, A Penman, M Holcombe
1Division of Infectious Disease, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA. rmwebb@umc.edu
Abstract:
The Mississippi State Department of Health tuberculosis program serves a rural southeastern US state of 2.9 million people in an area of 121,489 km(2) (46,907 square miles). Statewide, directly observed therapy (DOT) began in 1986. To evaluate the program's effectiveness, trends in Centers for Disease Prevention and Control program indicators for 1981-2005 were compared and found to be significant (P < 0.0001). Inclusion of rifampin and pyrazinamide in the regimens was reviewed. An annual decline in cases and case rates began in 1990, falling by 65% by 2005. Successful DOT is feasible over a large geographic area.
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