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Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)
10:02

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)

Published on: March 12, 2020

[Effectiveness and safety of methylphenidate and atomoxetine for attention deficit hyperactivity disorder: a

Xiao-Zhen Lv1, Zheng Shu, Yao-Wen Zhang

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|May 18, 2011
PubMed

Insights

Methylphenidate controlled-release (OROS-MPH) appears more effective than immediate-release methylphenidate (IR-MPH) for treating attention deficit hyperactivity disorder (ADHD) in children. Atomoxetine (AHC) showed similar effectiveness to IR-MPH, with all treatments demonstrating good safety profiles.

Area of Science:

  • Pediatric Psychiatry
  • Pharmacology
  • Clinical Trials

Background:

  • Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder in children.
  • Pharmacological interventions are a cornerstone of ADHD management.
  • Comparing the efficacy and safety of different ADHD medications is crucial for clinical decision-making.

Purpose of the Study:

  • To compare the effectiveness and safety of methylphenidate immediate-release tablets (IR-MPH), methylphenidate controlled-release tablets (OROS-MPH), and atomoxetine (AHC) in Chinese children diagnosed with ADHD.

Main Methods:

  • A systematic review and meta-analysis of randomized controlled trials (RCTs) and clinical controlled trials.
  • Searched major electronic databases including CNKI, VIP, CBMDISC, PubMed, Embase, and MEDLINE.
  • Independent data extraction and quality assessment by two reviewers.

Main Results:

  • Eight trials were included, demonstrating the efficacy of IR-MPH, OROS-MPH, and AHC for ADHD.
  • OROS-MPH showed superiority over IR-MPH in improving peer relationships, clinical global impression, mother satisfaction, and psychosomatic issues.
  • No significant differences in effectiveness were found between AHC and IR-MPH.

Conclusions:

  • OROS-MPH is likely more effective than IR-MPH for treating ADHD in children.
  • AHC demonstrates comparable effectiveness to IR-MPH.
  • All three medications (IR-MPH, OROS-MPH, AHC) are safe and well-tolerated, with no significant differences in adverse event rates.
Abstract

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