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[Clinical trial of cellulose in treatment of functional constipation in children]

Jun-Ping Lu1, Ying Huang, Ye Zhang

  • 1Children's Hospital of Fudan University, Shanghai 201102, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|May 18, 2011
PubMed

Insights

Cellulose effectively treats functional constipation in children, improving symptoms and stool consistency without adverse effects. This study confirms its safety and efficacy for pediatric constipation management.

Area of Science:

  • Pediatric Gastroenterology
  • Dietary Fiber Research
  • Clinical Trial Methodology

Background:

  • Functional constipation is a common pediatric condition.
  • Dietary interventions are a cornerstone of management.
  • Cellulose, a dietary fiber, is explored for its therapeutic potential.

Purpose of the Study:

  • To evaluate the efficacy and safety of cellulose in treating functional constipation in children.
  • To assess changes in constipation symptoms and fecal characteristics.

Main Methods:

  • A prospective, self-controlled clinical trial.
  • Involved 34 children diagnosed with functional constipation.
  • Treatment duration was 2 weeks with cellulose administration.

Main Results:

  • Significant improvements observed in fecal characteristics and constipation symptoms.
  • Total efficacy rates reached 37% (3 days), 87% (7 days), and 90% (14 days).
  • High satisfaction rates reported by physicians (57%) and parents (63%); no adverse events noted.

Conclusions:

  • Cellulose demonstrates significant efficacy in treating functional constipation in pediatric patients.
  • The treatment is well-tolerated, with a favorable safety profile.
  • Cellulose presents a safe and effective option for managing childhood functional constipation.
Abstract

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