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[Correlation between serum uric acid levels and obstructive sleep apnea/hypopnea syndrome in children]

Zhen-yun Huang1, Da-bo Liu, Gen-ping Wan

  • 1Department of Otorhinolaryngology, Guangzhou Women and Children's Medical Center, Guangzhou 510120, China.

Zhonghua Er Ke Za Zhi = Chinese Journal of Pediatrics
|May 18, 2011
PubMed

Insights

Serum uric acid (UA) levels were not elevated in children with obstructive sleep apnea/hypopnea syndrome (OSAHS). However, overweight and obese children, regardless of OSAHS, showed higher UA levels compared to normal BMI children.

Area of Science:

  • Pediatric Endocrinology
  • Sleep Medicine
  • Metabolic Disorders

Context:

  • Obstructive sleep apnea/hypopnea syndrome (OSAHS) is increasingly recognized in children.
  • Serum uric acid (UA) is a marker of metabolic health.
  • The relationship between UA levels and OSAHS in pediatric populations requires further investigation.

Purpose:

  • To investigate serum uric acid (UA) levels in children diagnosed with obstructive sleep apnea/hypopnea syndrome (OSAHS).
  • To analyze the correlation between serum UA and OSAHS severity indices.
  • To compare UA levels based on body mass index (BMI) in children with and without OSAHS.

Summary:

  • Serum UA levels did not significantly differ between children with OSAHS and controls.
  • Overweight and obese children, irrespective of OSAHS, exhibited significantly higher serum UA levels compared to normal BMI counterparts.
  • No significant correlation was found between serum UA levels and OSAHS severity indices (AHI, OAI, oxygen desaturation) in children.

Impact:

  • This study highlights that elevated serum UA in children is primarily associated with overweight and obesity, rather than OSAHS itself.
  • Findings suggest that managing weight may be crucial for normalizing UA levels in affected children.
  • Provides insights into the metabolic profile of pediatric OSAHS, differentiating contributing factors.
Abstract

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