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Suboptimal response to GnRHa long protocol is associated with a common LH polymorphism.

C Alviggi1, R Clarizia, K Pettersson

  • 1Dipartimento Universitario di Scienze Ostetriche Ginecologiche e Medicina della Riproduzione, Area Funzionale di Medicina della Riproduzione ed Endoscopia Ginecologica, Universitá degli Studi di Napoli Federico ll, Naples, Italy. alviggi@unina.it

Reproductive Biomedicine Online
|May 18, 2011
PubMed
Summary

The LH-β variant (v-βLH) may be linked to reduced ovarian response in women undergoing IVF treatment. This genetic factor appears more common in patients requiring higher doses of recombinant human FSH (rhFSH) due to resistance.

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Area of Science:

  • Reproductive Endocrinology
  • Human Genetics
  • In Vitro Fertilization (IVF)

Background:

  • Luteinizing hormone (LH) plays a crucial role in ovarian stimulation.
  • Genetic variations, such as LH-β variant (v-βLH), may influence hormonal function.
  • Understanding factors affecting ovarian response to FSH is vital for optimizing IVF outcomes.

Purpose of the Study:

  • To investigate the association between the LH-β variant (v-βLH) and ovarian response profiles.
  • To assess the relationship between v-βLH and recombinant human FSH (rhFSH) consumption in IVF patients.
  • To determine if v-βLH is more prevalent in women exhibiting resistance to rhFSH.

Main Methods:

  • Retrospective observational study of 60 normogonadotrophic women undergoing IVF/ICSI.
  • Patients were categorized into three groups based on total rhFSH dose administered (>3500 IU, 2000-3500 IU, <2000 IU).
  • LH-β variant (v-βLH) presence was assessed using immunoassays; oestradiol levels and oocyte yield were analyzed.

Main Results:

  • Women requiring >3500 IU rhFSH (Group A) showed significantly lower peak oestradiol levels and fewer oocytes retrieved compared to other groups.
  • The v-βLH was detected in 31.8% of women in Group A, versus 6.7% in Group B and 0% in Group C.
  • These findings suggest a higher frequency of v-βLH in women with diminished ovarian response to rhFSH.

Conclusions:

  • The LH-β variant (v-βLH) may be associated with ovarian resistance to rhFSH.
  • v-βLH could be a contributing factor to reduced ovarian response in certain IVF patient populations.
  • Further research is warranted to confirm the clinical implications of v-βLH in fertility treatments.