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In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

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Related Experiment Video

Updated: Jun 2, 2026

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Published on: October 24, 2025

Individualizing FSH dose for assisted reproduction using a novel algorithm: the CONSORT study.

F Olivennes¹, C M Howies, A Borini

¹Merck Serono SA, Geneva, Switzerland. francois.olivennes@gmail.com

Reproductive Biomedicine Online

|May 18, 2011

Summary

This summary is machine-generated.

The CONSORT dosing algorithm individualizes recombinant human FSH (r-hFSH) doses for assisted reproduction. This pilot study showed adequate oocyte yield and good pregnancy rates, suggesting algorithm adjustments could reduce cancellations.

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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

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Published on: September 16, 2021

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Last Updated: Jun 2, 2026

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Published on: October 24, 2025

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

Area of Science:

Reproductive Endocrinology
Assisted Reproductive Technologies
Pharmacometrics

Background:

Individualized dosing of recombinant human FSH (r-hFSH) is crucial for optimizing outcomes in assisted reproduction technologies (ART).
The CONSORT algorithm was developed to personalize r-hFSH doses based on key patient characteristics.
Previous methods for FSH dosing lacked consistent individualization, potentially impacting treatment efficacy and safety.

Purpose of the Study:

To evaluate the efficacy and safety of the CONSORT dosing algorithm for individualizing r-hFSH doses in normo-ovulatory women undergoing ART.
To assess the number of oocytes retrieved and clinical pregnancy rates associated with algorithm-assigned r-hFSH doses.
To identify potential areas for algorithm refinement, such as reducing cancellation rates due to inadequate response.

Main Methods:

A prospective, uncontrolled, international pilot study involving 18 centers.
Normo-ovulatory women aged 18-34 years received follitropin alfa (GONAL-f®) doses determined by the CONSORT algorithm using a long agonist protocol.
Doses were adjusted primarily for OHSS risk; primary endpoint was oocytes retrieved.

Main Results:

Median oocyte retrieval was 9.0 across all groups. Higher dose groups (187.5 IU) showed higher oocyte yields.
Clinical pregnancy rates per cycle started ranged from 31.3% to 50.0%, with an overall rate of 34.2%.
Cancellations due to inadequate response were higher in the lowest dose group (75 IU). Two cases of severe OHSS were reported.

Conclusions:

The CONSORT algorithm demonstrated potential for achieving adequate oocyte yield and favorable pregnancy rates in a preliminary ART study.
The algorithm's current structure may lead to higher cancellation rates in lower dose groups, indicating a need for adjustment.
Further refinement of the CONSORT algorithm could enhance its effectiveness in minimizing cancellations and optimizing ART outcomes.