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Related Experiment Video

Updated: Jun 2, 2026

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Published on: August 21, 2019

Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer

David H Nguyen¹, Hellen A Oketch-Rabah, Irineu Illa-Bochaca

¹Department of Radiation Oncology, New York University School of Medicine, New York, NY 10016, USA.

|May 18, 2011

Summary

This summary is machine-generated.

Ionizing radiation exposure accelerates aggressive tumor development by altering the tissue microenvironment. This involves transforming growth factor-beta (TGFβ) and impacting mammary stem cell activity, leading to distinct tumor characteristics.

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Growth and Characterization of Irradiated Organoids from Mammary Glands

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Published on: May 3, 2019

Area of Science:

Oncology
Radiation Biology
Cancer Microenvironment Research

Background:

The tissue microenvironment significantly influences carcinogenesis and cancer progression.
Ionizing radiation is a known environmental carcinogen with complex effects on cancer development.

Discussion:

Ionizing radiation exposure alters the mammary tissue microenvironment, promoting accelerated and aggressive tumor development.
Transforming growth factor-beta (TGFβ) plays a key role in mediating radiation-induced tumor acceleration.
Radiation-induced tumors exhibit distinct molecular signatures and a higher prevalence of estrogen receptor negativity, linked to mammary stem cell activity.

Key Insights:

Irradiated host microenvironments accelerate aggressive tumor formation in oncogenic epithelium.
TGFβ signaling mediates the acceleration of tumor latency.
Estrogen receptor negativity in radiation-associated tumors is TGFβ-independent and linked to stem cell activity.

Outlook:

Further research into radiation-induced microenvironmental changes can reveal novel therapeutic targets.
Understanding the interplay between radiation, TGFβ, and stem cells is crucial for cancer prevention and treatment strategies.
Investigating the mechanisms behind ER negativity in radiation-associated cancers may offer insights into treatment resistance.