Related Experiment Video
Updated: Jun 2, 2026
Laparoscopic Non-Mesh Cerclage Pectopexy with Uterine Preservation for Pelvic Organ Prolapse
Published on: October 25, 2024
A double-blind randomized controlled trial of vaginal misoprostol for cervical priming before outpatient hysteroscopy
Akmal El-Mazny1, Nermeen Abou-Salem
1Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt. dr_akmalelmazny@yahoo.com
Objective:
To evaluate the efficacy and safety of vaginal misoprostol for cervical priming before diagnostic outpatient hysteroscopy (OH) without anesthesia.
Design:
Double-blind randomized controlled trial.
Setting:
University teaching hospital.
Patient(S):
One hundred fifty patients requiring diagnostic OH for investigation of infertility or abnormal uterine bleeding in the reproductive age.
Intervention(S):
Patients were randomly allocated into two equal groups (n = 75). In group I, 200 μg misoprostol was inserted into the posterior vaginal fornix 3 hours before OH; in group II (control), vaginal examination was performed without misoprostol administration. A rigid 30° 4-mm hysteroscope was used in the vaginoscopic technique.
Main Outcome Measure(S):
Ease of cervical entry (Likert scale), procedural time, patient acceptability (Likert scale), and pain scoring (visual analog scale).
Result(S):
Vaginal misoprostol significantly facilitated the procedure; cervical entry was easier, procedural time was shorter, patient acceptability was higher, and pain scoring was lower in group I compared with group II. Side effects of misoprostol were infrequent, minor, and transient. No complications were reported.
Conclusion(S):
The regimen of 200 μg vaginal misoprostol administered 3 hours before diagnostic OH is a simple, effective, and safe method of cervical priming to facilitate the procedure without anesthesia.
