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Updated: Jun 2, 2026

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics
Published on: January 5, 2024
bla(KPC) RNA expression correlates with two transcriptional start sites but not always with gene copy number in four
Amanda L Roth1, Philip M Kurpiel, Philip D Lister
1Center for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA.
Abstract:
Klebsiella pneumoniae carbapenemase (KPC)-producing organisms are therapeutically and diagnostically challenging. It is possible that bla(KPC) gene expression plays a role in the variability observed in clinical susceptibility testing. bla(KPC) transformants together with 10 clinical isolates representing four genera were evaluated for bla(KPC) copy number and gene expression and correlated with β-lactam MIC data. The data suggest that mechanisms other than gene copy number and expression of bla(KPC) contribute to variability in susceptibility when testing KPC-producing isolates.
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