Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic analysis of oesophageal carcinoma (EC) identifies recurrent mutations in histone methyltransferases as a distinctive subset.

Oncogene·2026
Same author

Activation of the endocytosis pathway stratifies subtypes and therapeutic sensitivity in colorectal cancer.

Research square·2026
Same author

Endoplasmic reticulum-targeted gold nanorod for chemo-photothermal therapy induces ER stress-mediated autophagy and apoptosis in cancer cells.

Journal of materials chemistry. B·2026
Same author

Rationally designed mitochondria-impairing small molecule-enabled chemo-phototherapy to potentiate apoptosis and autophagy in cancer cells.

Journal of materials chemistry. B·2026
Same author

Activating a B cell immune response regresses immunologically cold tumours.

Nature nanotechnology·2026
Same author

From biomass to bioactivity: <i>Butea monosperma</i> bark-derived carbon quantum dots for benzopyran synthesis and their <i>in silico</i> studies.

RSC advances·2026

Related Experiment Video

Updated: Jun 2, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

Rationally engineered polymeric cisplatin nanoparticles for improved antitumor efficacy.

Abhimanyu Paraskar1, Shivani Soni, Sudipta Basu

  • 1BWH-HST Center for Biomedical Engineering, Harvard Medical School, Cambridge, MA 02139, USA.

Nanotechnology
|May 18, 2011
PubMed
Summary

This study developed a novel cisplatin nanoparticle using PEG-PIMA copolymer. The engineered nanoparticle shows comparable potency, enhanced antitumor efficacy, and reduced kidney toxicity in a breast cancer model.

More Related Videos

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
07:47

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Published on: December 13, 2015

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Related Experiment Videos

Last Updated: Jun 2, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
07:47

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Published on: December 13, 2015

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
10:42

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Area of Science:

  • Nanomedicine
  • Materials Science
  • Oncology

Background:

  • Cisplatin is a vital chemotherapy drug, but its use is limited by dose-dependent nephrotoxicity.
  • Previous nanotechnology approaches to cisplatin delivery have compromised drug potency.
  • Developing effective cisplatin nanocarriers with preserved efficacy and reduced side effects is crucial.

Purpose of the Study:

  • To rationally engineer a novel cisplatin nanoparticle with preserved potency and reduced nephrotoxicity.
  • To evaluate the efficacy and biodistribution of the engineered cisplatin nanoparticle in a preclinical cancer model.

Main Methods:

  • A novel polyethylene glycol-functionalized poly-isobutylene-maleic acid (PEG-PIMA) copolymer was synthesized to complex with cisplatin.
  • The complex self-assembled into nanoparticles, characterized for size and cisplatin release kinetics.
  • In vitro cytotoxicity and in vivo antitumor efficacy and biodistribution studies were performed using a 4T1 breast cancer model.

Main Results:

  • The PEG-PIMA-cisplatin nanoparticle exhibited an IC(50) comparable to free cisplatin.
  • Nanoparticles were internalized by cancer cells and released cisplatin in a pH-dependent manner.
  • In vivo studies demonstrated improved antitumor efficacy with reduced nephrotoxicity and preferential tumor accumulation.

Conclusions:

  • The PEG-PIMA-cisplatin nanoparticle offers a promising strategy to overcome cisplatin's limitations.
  • This nanomedicine approach enhances therapeutic efficacy while mitigating dose-limiting toxicities.
  • Rational nanoparticle engineering can lead to improved cancer chemotherapy outcomes.