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Updated: Jun 1, 2026
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Published on: November 11, 2025
Overweight is an additional prognostic factor in acute pancreatitis: a meta-analysis
Shi-qi Wang1, Shu-jun Li, Quan-xin Feng
1Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, Shaanxi Province, China.
Summary
Overweight individuals with acute pancreatitis (AP) face a higher risk of severe AP, local complications, and mortality. This study confirms obesity also worsens AP prognosis.
Area of Science:
- Gastroenterology
- Clinical Medicine
- Public Health
Background:
- Obesity is linked to poor outcomes in acute pancreatitis (AP).
- The impact of overweight on AP prognosis remains unclear.
- This study investigates the correlation between overweight and AP outcomes.
Purpose of the Study:
- To determine if overweight status is a prognostic factor in acute pancreatitis.
- To analyze the association between body mass index (BMI) and AP severity, complications, and mortality.
Main Methods:
- A meta-analysis of prospective clinical studies was conducted.
- Searched MEDLINE and PubMed for studies on AP, obesity, overweight, and BMI.
- Endpoints included severe AP, local complications, systemic complications, and mortality.
Main Results:
- Eight studies with 939 patients were analyzed.
- Overweight patients had increased rates of severe AP, local complications, and mortality.
- Obesity was confirmed as a factor for poor AP prognosis.
Conclusions:
- Overweight status is an independent prognostic factor for AP severity.
- Overweight is associated with increased local complications and mortality in AP.
- Findings highlight the importance of weight status in managing AP.
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