Related Experiment Video
Updated: Jun 1, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022
Cutaneous manifestations of malignancy
1Texas Children's Hospital and Baylor College of Medicine, Houston, Texas, USA. tswright@texaschildrens.org
Purpose Of Review:
Many types of cancer can cause lesions to appear on the skin. Cutaneous manifestations may be primary or secondary to an underlying malignancy. Skin lesions may appear prior to the onset of systemic malignancy or they may occur concurrently or following an established diagnosis. The purpose of this review is to educate medical providers about several types of pediatric malignancies that can present with cutaneous findings. The primary focus of this review will be cutaneous features of leukemias, lymphomas, neuroblastoma, some sarcomas, and Langerhans cell histiocytosis.
Recent Findings:
A wide range of cutaneous manifestations have been reported in systemic malignancies of children. In addition to providing a description of more typical features of skin lesions associated with these conditions, this review will summarize a few recent case reports of pediatric malignancies with unusual cutaneous presentations.
Summary:
Systemic malignancy can present with a variety of cutaneous manifestations. Given that accurate, prompt diagnosis of malignancy can have tremendous prognostic significance, it is imperative that clinicians are familiar with features of skin lesions that may be seen in this setting.
Related Concept Videos
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Changes in Skin Color: Clinical Perspectives
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Pigmentation
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Healing II: Complications
Staphylococcal Skin Infections