Related Experiment Video

Updated: Jun 1, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

Role of macrophages in the progression of acute pancreatitis

Sabrina Gea-Sorlí1, Daniel Closa

  • 1Sabrina Gea-Sorlí, Daniel Closa, Department of Experimental Pathology, IIBB-CSIC-IDIBAPS-CIBEREHD, Barcelona 08036, Spain.

World Journal of Gastrointestinal Pharmacology and Therapeutics
|May 18, 2011
PubMed

Insights

Macrophages are key inflammatory cells in acute pancreatitis. Understanding their gene expression regulation is crucial for developing new therapies targeting pancreatic inflammation.

Area of Science:

  • Immunology
  • Gastroenterology
  • Cell Biology

Background:

  • Acute pancreatitis involves inflammatory mediators from damaged pancreas.
  • Macrophages, including peritoneal, alveolar, and Kupffer cells, are activated during pancreatitis.
  • Macrophages exhibit plasticity, with diverse activation pathways and phenotypes based on microenvironmental cues.

Purpose of the Study:

  • To explore the role of macrophages in acute pancreatitis.
  • To investigate the therapeutic potential of modulating macrophage function.
  • To highlight the need for understanding gene expression regulation in macrophages for therapeutic development.

Main Methods:

  • Review of existing literature on macrophage activation in acute pancreatitis.
  • Analysis of macrophage plasticity and phenotypic heterogeneity.
  • Discussion of therapeutic strategies targeting macrophage function.

Main Results:

  • Macrophages are significant contributors to inflammatory mediator generation in acute pancreatitis.
  • Macrophage activation and heterogeneity are influenced by the pancreatic microenvironment.
  • Current therapeutic strategies show promise but require deeper understanding.

Conclusions:

  • Macrophages are critical players in the inflammatory response during acute pancreatitis.
  • Targeting macrophage plasticity offers therapeutic potential for pancreatitis.
  • Further research into macrophage gene expression is essential for effective in vivo therapies.
Keywords:
InflammationMacrophagesPancreatitisSystemic inflammatory response syndrome

More Related Videos

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Related Concept Videos

Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...