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Thrombin antithrombin complex and IL-18 serum levels in stroke patients
Ornella Piazza1, Giuliana Scarpati, Simona Cotena
1Università degli Studi di Napoli Federico II, Anestesiologia e Rianimazione, Napoli, Italy.
Neurology International
|May 18, 2011
Summary
Inflammation and coagulation markers (S100B, IL-18, TAT, D-dimer, FDP) were elevated in acute stroke patients. Targeting both inflammation and coagulation may improve stroke therapy outcomes.
Area of Science:
- Neuroscience
- Immunology
- Hematology
Background:
- Acute stroke involves complex inflammation and coagulation alterations.
- Evidence suggests crosstalk between inflammatory and coagulation systems.
- Antithrombin III (ATIII) shows potential neuroprotective and anti-inflammatory effects in ischemic models.
Purpose of the Study:
- To investigate the relationship between inflammation markers (S100B, IL-18) and coagulation markers (ATIII, TAT, FDP, D-dimer) in acute focal cerebral ischemia.
- To explore the extent of crosstalk between these systems in stroke patients.
Main Methods:
- Analysis of plasma levels of S100B, IL-18, ATIII, thrombin-antithrombin III complex (TAT), Fibrin Degradation Products (FDP), and D-dimer.
- Study included 13 comatose patients with focal cerebral ischemia.
Main Results:
- Elevated plasma levels of TAT, D-dimer, FDP, IL-18, and S100B were observed in ischemic patients.
- High serum levels of IL-18 and S100B indicate early inflammatory cascade activation in acute ischemic injury.
Conclusions:
- The findings support a significant interaction between inflammatory and coagulation systems in acute ischemic stroke.
- Simultaneous modulation of both systems, rather than targeting one alone, may offer a more effective therapeutic strategy for stroke.
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