Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vibration exposure and peripheral nerve fiber damage.

G Lundborg1, L B Dahlin, H A Hansson

  • 1Department of Hand Surgery, University of Lund, Malmö General Hospital, Sweden.

The Journal of Hand Surgery
|March 1, 1990
PubMed
Summary

Vibration exposure caused subtle nerve damage in rat hind legs, particularly affecting unmyelinated fibers. This damage, however, enhanced nerve regeneration, suggesting a "conditioning effect" on neuronal repair.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Professor Nils Carstam, MD, PhD, 13 September 1913-28 May 2014.

The Journal of hand surgery, European volume·2014
Same author

Resorbable filament structures as a scaffold for matrix formation and axonal growth in bioartificial nerve grafts: long term observations.

Restorative neurology and neuroscience·2011
Same author

An experimental study of nerve grafting combined with silicone tubes in the rat model: Functional outcome and specificity of muscle reinnervation.

Restorative neurology and neuroscience·2011
Same author

Effects of human growth hormone on peripheral nerve regeneration.

Restorative neurology and neuroscience·2011
Same author

Nerve regeneration problems in a clinical perspective.

Restorative neurology and neuroscience·2011
Same author

Pulsed electromagnetic fields stimulate nerve regeneration in vitro and in vivo.

Restorative neurology and neuroscience·2011

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Occupational Health

Background:

  • Occupational exposure to vibration is common.
  • Understanding vibration's effects on peripheral nerves is crucial for worker safety.
  • Previous research has not fully elucidated the microstructural impact of vibration on nerve fibers.

Purpose of the Study:

  • To investigate the ultrastructural effects of controlled vibration exposure on rat peripheral nerves.
  • To assess the reversibility of any observed nerve damage.
  • To determine if vibration exposure influences nerve regeneration capacity.

Main Methods:

  • Adult rats were subjected to controlled hind leg vibration (82 Hz, 0.21 mm peak-to-peak) for 4 hours daily over 5 days.
  • Plantar and sciatic nerves were examined using light and electron microscopy immediately and 2-4 weeks post-exposure.

Related Experiment Videos

  • Sciatic nerve crush injury model was used to assess regeneration after vibration exposure.

    • Main Results:

    • Light microscopy showed no significant injury.
    • Electron microscopy revealed ultrastructural changes in unmyelinated plantar nerve fibers, including axoplasmic derangement and smooth endoplasmic reticulum accumulation.
    • These vibration-induced changes were reversible within 4 weeks.
    • Vibration exposure prior to sciatic nerve crush injury increased axonal outgrowth by 23% compared to controls.

    Conclusions:

    • Vibration exposure induces reversible ultrastructural damage in unmyelinated peripheral nerve fibers.
    • This damage acts as a "conditioning effect," enhancing the nerve fiber regeneration potential.
    • Findings suggest a need for further research into vibration-induced nerve plasticity and its implications for occupational health.