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Updated: Jun 1, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
4-(Benzyl-ideneamino)benzene-sulfonamide
Bradley T Loughrey1, Michael L Williams, Peter C Healy
1Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane 4111, Australia.
This study details the crystal structure of a Schiff base derived from benzaldehyde and sulfanilamide. The compound forms a 2D array through specific hydrogen bonds, revealing molecular geometry and bonding interactions.
Area of Science:
- Crystallography
- Supramolecular Chemistry
- Organic Chemistry
Background:
- Schiff bases are versatile compounds with diverse applications.
- Sulfanilamide is a key antibacterial sulfonamide.
Purpose of the Study:
- To characterize the crystal structure of a novel Schiff base formed from benzaldehyde and sulfanilamide.
- To investigate the intermolecular interactions and molecular geometry.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the crystal structure.
- Analysis of hydrogen bonding networks and torsion angles.
Main Results:
- The compound C(13)H(12)N(2)O(2)S crystallizes as discrete molecules.
- N-H⋯N and N-H⋯O hydrogen bonds link molecules into a 2D array in the bc plane.
- Specific torsion and dihedral angles describe the molecular conformation.
Conclusions:
- The study elucidates the solid-state structure and intermolecular forces of the synthesized Schiff base.
- The findings contribute to understanding the structure-property relationships in sulfanilamide derivatives.
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