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Updated: Jun 1, 2026
11:01
Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
N'-[4-(Dimethyl-amino)benzyl-idene]acetohydrazide
Summary
This study details the crystal structure of a compound, C(11)H(15)N(3)O. Two independent molecules with slightly different side-chain orientations form hydrogen-bonded dimers and zigzag chains.
Area of Science:
- Crystallography
- Chemical Physics
Background:
- Understanding molecular arrangements in solid-state is crucial for predicting material properties.
- Crystal structure analysis provides fundamental insights into intermolecular interactions.
Purpose of the Study:
- To elucidate the crystal structure of the title compound, C(11)H(15)N(3)O.
- To investigate the molecular conformations and intermolecular interactions in the crystal lattice.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the crystal structure.
- Analysis of torsion angles and hydrogen bonding patterns was performed.
Main Results:
- The asymmetric unit contains two independent molecules with variations in side-chain orientation (C=N-N-C torsion angles of -176.2(3)° and -179.83(3)°).
- Both molecules adopt a trans configuration around the C=N bond.
- These molecules form N-H⋯O hydrogen-bonded dimers, which further assemble into zigzag chains along the [100] direction via C-H⋯O hydrogen bonds.
Conclusions:
- The crystal packing is governed by a combination of N-H⋯O and C-H⋯O hydrogen bonds.
- The observed molecular arrangement offers insights into the solid-state behavior of this compound.
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